Scott R Mackenzie Foundation Inc
Jacksonville, FL · EIN 463383293 990-PF tax year 2024
Historical funder research: IRS Form 990-PF filings from US private foundations, showing who funded what in past years. This is not a list of currently open grant calls, and we do not track open RFPs from private foundations. From public IRS Form 990-PF filings (latest on file for this funder: tax year 2024). Coverage: tax years 2019–2025. Freshness: the IRS releases these returns 1.5–2+ years after the tax year ends, so 2025 is still partial and a funder's newest grants may not appear yet. Last updated: November 14, 2026. Filings can contain errors, so confirm current priorities and deadlines with the funder before applying.
Grants paid (tax yr 2024)
$960,916
Assets (fair market value)
$24,535,320
Median grant to orgs
$149,584
all loaded years
Grants in our data
23
since tax year 2021
Giving by tax year
$1,008,269
2021
6 grants
$1,200,000
2022
6 grants
$1,202,529
2023
6 grants
$960,916
2024
5 grants
Year 2025 is still partial because many returns have not been filed or released yet. That is a freshness issue — coverage in our dataset is tax years 2019–2025.
Top recipient states
ME$1,885,000
FL$1,088,214
OH$350,000
AZ$350,000
NJ$300,000
GA$250,000
NY$148,500
Cause areas funded
Science & Technology4
Diseases & Disorders1
Education2
Medical Research1
Only 34.8% of this funder's organizational grants could be linked to an IRS cause code.
How to apply (from the 990-PF, tax year 2024)
- Form & materials
- AN ELIGIBLE 501(C)(3) ORGANIZATION CAN GO TO WWW.SCOTTRMACKENZIEFOUNDATION.COM AND FOLLOW THE INSTRUCTIONS FOR APPLYING FOR A GRANT.
- Deadlines
- INITIAL GRANT APPLICATION: APRIL 30TH; FINAL GRANT APPLICATION: JUNE 30TH
- Restrictions
- FUNDING IS AVAILABLE FOR AMERICAN-BASED ORGANIZATIONS WITH A MISSION TO FIND A CURE FOR: CANCER LUNG DISEASE (INCLUDING ASTHMA) DIABETES HEART DISEASE
Recent grants to organizations
| Recipient | Location | Purpose (as filed) | Amount | Tax yr |
|---|---|---|---|---|
| Mount Desert Island Biological Laboratory | Bar Harbor, ME | THIS PROJECT SEEKS TO CONTINUE THE PROJECT AWARDED IN 2022 TO ESTABLISH A NOVEL TREATMENT STRATEGY FOR DIABETIC KIDNEY DISEASE. PREVIOUS SUPPORT FROM THE MACKENZIE FOUNDATION IS ALLOWING MDI BIO LAB TO UNDERSTAND THE STRUCTURE AND FUNCTIONAL PARTS OF THE HPA2 MOLECULE AND ESTABLISH A BASELINE FROM WHICH TO FULLY UNDERSTAND ITS FUNCTION. BASED ON THIS ONGOING WORK, MDI BIO LAB NOW SEEKS TO INVESTIGATE THE EFFECT OF DIABETES IN A MODEL ORGANISM OF AGING (AFRICAN TURQUOISE KILLIFISH). SIMULTANEOUSLY, MDI BIO LAB ALSO PROPOSES TO USE THIS MODEL TO STUDY THE LOSS OF PERITUBULAR CAPILLARIES OBSERVED DURING KIDNEY AGING. | $450,000 | 2024 |
| HMH Hospitals Corporation | Edison, NJ | YEAR 2 FUNDING - THIS PROJECT SEEKS TO FOCUS ON QUANTIFYING SELECTIVE PRESSURES APPLIED BY NUCLEOTIDE DEPLETION AND GENOMIC STRESS IN ORDER TO DISSECT THE EVOLUTIONARY DYNAMICS OF CANCER CELLS ACROSS MULTIPLE TUMOR TYPES, INCLUDING LEUKEMIA, LYMPHOMA, MYELOMA, COLORECTAL CANCER, MELANOMA, AND RETINOBLASTOMA. | $150,000 | 2024 |
| University of Florida Foundation | Gainesville, FL | YEAR 2 FUNDING - THIS PROJECT SEEKS TO IDENTIFY DEPENDENCIES OF TUMOR CELLS IN DEEP MARGINS BY PERFORMING SINGLE-CELL SEQUENCING ON LARGER COHORT OF TUMORS THE GRANTEE COLLECTED (N=28) AND TESTING THEIR FINDINGS IN MODEL SYSTEMS. THUS, THE STUDY WOULD OPEN NEW AVENUES FOR THERAPIES TARGETING SPECIFIC TRAITS WITHIN TUMOR CELLS DRIVING RECURRENCE, AND FOR IMPROVED STRATEGIES RELEASING THE HOST IMMUNE SYSTEM AGAINST GLIOBLASTOMA. | $149,345 | 2024 |
| University of Florida Foundation | Gainesville, FL | YEAR 2 FUNDING - THIS PROJECT SEEKS TO DEFINE TREATMENT REGIMENS OF BLOOD THINNING MEDICATIONS ASSOCIATED WITH REDUCED RISK OF RECURRENT HEART ATTACKS, WHICH MAY INCLUDE THE USE OF THE MORE POTENT BLOOD THINNER TICAGRELOR ALSO IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE. | $125,000 | 2024 |
| University of Miami College of Medicine | Coral Gables, FL | YEAR 2 FUNDING - THIS PROJECT SEEKS TO UTILIZE GENERATIVE ADVERSARIAL NETWORK (GAN) MODELS TO CREATE HIGH-QUALITY SYNTHETIC IMAGES REPRESENTING VARIOUS PROSTATE CANCER (PCA) GRADES. THESE IMAGES WILL BE TAILORED TO ACCOUNT FOR THE MORPHOLOGICAL AND GENOMIC GRANULARITY ASSOCIATED WITH EACH GLEASON GRADE WHILE REQUIRING SIGNIFICANTLY SMALLER TRAINING DATA SAMPLES. PRELIMINARY DATA INDICATES THAT THIS APPROACH CONSIDERABLY ENHANCES AI MODELS' PROGNOSTIC CAPABILITIES FOR PCA. | $86,571 | 2024 |
| Mount Desert Island Biological Laboratory | Bar Harbor, ME | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO CONTINUE THE PROJECT AWARDED IN 2022 TO ESTABLISH A NOVEL TREATMENT STRATEGY FOR DIABETIC KIDNEY DISEASE. PREVIOUS SUPPORT FROM THE MACKENZIE FOUNDATION IS ALLOWING MDI BIO LAB TO UNDERSTAND THE STRUCTURE AND FUNCTIONAL PARTS OF THE HPA2 MOLECULE AND ESTABLISH A BASELINE FROM WHICH TO FULLY UNDERSTAND ITS FUNCTION. BASED ON THIS ONGOING WORK, MDI BIO LAB NOW SEEKS TO INVESTIGATE THE EFFECT OF DIABETES IN A MODEL ORGANISM OF AGING (AFRICAN TURQUOISE KILLIFISH). SIMULTANEOUSLY, MDI BIO LAB ALSO PROPOSES TO USE THIS MODEL TO STUDY THE LOSS OF PERITUBULAR CAPILLARIES OBSERVED DURING KIDNEY AGING. | $450,000 | 2023 |
| Emory University Grants | Atlanta, GA | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO OPTIMIZE AND VALIDATE A COMPUTATIONAL PATHOLOGY-BASED IMAGE RISK PREDICTOR (OVARISC) THAT PREDICTS OUTCOME AND RESPONSE IN ADVANCED OCA RECEIVING PRIMARY PLATINUM-BASED COMBINATION CHEMOTHERAPY, AND TO CONFIRM THE ASSOCIATION BETWEEN OVARISC SCORES AND RESPONSE TO ICI ON A BLINDED VALIDATION SET OBTAINED FROM AN INDEPENDENT CLINICAL TRIAL. | $250,000 | 2023 |
| HMH Hospitals Corporation | Edison, NJ | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO FOCUS ON QUANTIFYING SELECTIVE PRESSURES APPLIED BY NUCLEOTIDE DEPLETION AND GENOMIC STRESS IN ORDER TO DISSECT THE EVOLUTIONARY DYNAMICS OF CANCER CELLS ACROSS MULTIPLE TUMOR TYPES, INCLUDING LEUKEMIA, LYMPHOMA, MYELOMA, COLORECTAL CANCER, MELANOMA, AND RETINOBLASTOMA. | $150,000 | 2023 |
| University of Florida Foundation | Gainesville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO IDENTIFY DEPENDENCIES OF TUMOR CELLS IN DEEP MARGINS BY PERFORMING SINGLE-CELL SEQUENCING ON LARGER COHORT OF TUMORS THE GRANTEE COLLECTED (N=28) AND TESTING THEIR FINDINGS IN MODEL SYSTEMS. THUS, THE STUDY WOULD OPEN NEW AVENUES FOR THERAPIES TARGETING SPECIFIC TRAITS WITHIN TUMOR CELLS DRIVING RECURRENCE, AND FOR IMPROVED STRATEGIES RELEASING THE HOST IMMUNE SYSTEM AGAINST GLIOBLASTOMA. | $149,584 | 2023 |
| University of Florida Foundation | Gainesville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO SEEK TO DEFINE TREATMENT REGIMENS OF BLOOD THINNING MEDICATIONS ASSOCIATED WITH REDUCED RISK OF RECURRENT HEART ATTACKS, WHICH MAY INCLUDE THE USE OF THE MORE POTENT BLOOD THINNER TICAGRELOR ALSO IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE. | $125,000 | 2023 |
| University of Miami College of Medicine | Coral Gables, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO UTILIZE GENERATIVE ADVERSARIAL NETWORK (GAN) MODELS TO CREATE HIGH-QUALITY SYNTHETIC IMAGES REPRESENTING VARIOUS PROSTATE CANCER (PCA) GRADES. THESE IMAGES WILL BE TAILORED TO ACCOUNT FOR THE MORPHOLOGICAL AND GENOMIC GRANULARITY ASSOCIATED WITH EACH GLEASON GRADE WHILE REQUIRING SIGNIFICANTLY SMALLER TRAINING DATA SAMPLES. PRELIMINARY DATA INDICATES THAT THIS APPROACH CONSIDERABLY ENHANCES AI MODELS' PROGNOSTIC CAPABILITIES FOR PCA. | $77,945 | 2023 |
| Mount Desert Island Biological Laboratory | Bar Harbor, ME | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO SEEK TO PREVENT ORGAN COMPLICATIONS IN DIABETIC PATIENTS. HIGH GLUCOSE LEVELS LEAD TO THE PATHOLOGICAL CHANGES IN THE VASCULATURE OF DIFFERENT ORGANS SUCH AS THE HEART, KIDNEY, EYE AND PERIPHERAL CIRCULATION. THE FOCUS IS THE MICROCIRCULATION OF THE KIDNEY. THE ENDOTHELIAL CELL SURFACE IS COVERED WITH A LAYER OF GLYCOCALYX. THE GLYCOCALYX IS VERY IMPORTANT FOR THE HEALTH OF THE VASCULAR WALL AND REGULATES CENTRAL MECHANISMS SUCH AS METABOLISM, INFLAMMATION, BLOOD PRESSURE, ETC. WE WILL TEST THE HYPOTHESIS THAT RECOMBINANT HPA2 AMELIORATES DIABETIC NEPHROPATHY BY MAINTAINING A FUNCTIONAL HEPARAN SULFATE GLYCOCALYX ON ENDOTHELIAL CELLS AND MONOCYTES. THIS IS A CONTINUATION OF THE PROJECT FUNDED IN 2021. | $450,000 | 2022 |
| Cincinnati Cancer Foundation Inc | Cincinnati, OH | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO ESTABLISH THE ADVANCING PRECISION ONCOLOGY CENTER ("APOC"), WHOSE PURPOSE IS TO ENABLE PATIENT ACCESS TO A WIDE RANGE OF NGS TESTING INTENDED TO FACILITATE EARLY DETECTION, BETTER OUTCOMES, AND BETTER POSSIBILITIES FOR CANCER CURES THROUGH EARLIER DETECTION AND INTERVENTION. | $350,000 | 2022 |
| University of Arizona | Tucson, AZ | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO SEEK TO IMPROVE THE DIAGNOSIS AND TREATMENT OF ATRIAL FIBRILLATION. TODEVELOP PATIENT-SPECIFIC TARGETED NEXT-GENERATION GENE SEQUENCING FOR PREDICTING AND DIAGNOSING ATRIAL FIBRILLATION AND ESTABLISH A PATIENT-SPECIFIC STEM CELL PLATFORM FOR DEVELOPING PRECISION MEDICINE BASED TREATMENTS. | $174,994 | 2022 |
| The Jackson Laboratory | Bar Harbor, ME | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO INVESTIGATE AGING-RELATED RNA SPLICING ALTERATIONS TO REVEAL NOVEL BIOMARKERS FOR QUANTIFYING BREAST CANCER RISK AND NEW TARGETS FOR TREATING BREAST CANCER. | $135,000 | 2022 |
| University of Florida Foundation | Gainesville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO SEEK TO TEST GENETIC ASSOCIATIONS WITH CHILDREN'S RESPONSE TO ALBUTEROL AND BEGIN A LONGITUDINAL PEDIATRIC ASTHMA REGISTRY COMBINING CLINICAL AND GENOMIC DATA. | $57,500 | 2022 |
| Mayo Clinic | Jacksonville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THIS GIFT TO SUPPORT THE TAPESTRY STUDY. | $32,506 | 2022 |
| Mount Desert Island Biological Laboratory | Bar Harbor, ME | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO PREVENT ORGAN COMPLICATIONS IN DIABETIC PATIENTS. HIGH GLUCOSE LEVELS LEAD TO THE PATHALOGICAL CHANGES IN THE VASCULATURE OF DIFFERENT ORGANS SUCH AS THE HEART, KIDNEY, EYE AND PERIPHERAL CIRCULATION. THE FOCUS IS THE MICROCIRCULATION OF THE KIDNEY. THE ENDOTHELIAL CELL SURFACE IS COVERED WITH A LAYER OF GLYCOCALYX. THE GLYCOCALYX IS VERY IMPORTANT FOR THE HEALTH OF THE VASCULAR WALL AND REGULATES CENTRAL MECHANISMS SUCH AS METABOLISM, INFLAMMATION, BLOOD PRESSURE, ETC. WE WILL TEST THE HYPOTHESIS THAT RECOMBINANT HPA2 AMELIORATES DIABETIC NEPHROPATHY BY MAINTAINING A FUNCTIONAL HEPARAN SULFATE GLYCOCALYX ON ENDOTHELIAL CELLS AND MONOCYTES. | $400,000 | 2021 |
| University of Arizona | Tucson, AZ | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO IMPROVE THE DIAGNOSIS AND TREATMENT OF ATRIAL FIBRILLATION. TO DEVELOP PATIENT-SPECIFIC TARGETED NEXT-GENERATION GENE SEQUENCING FOR PREDICTING AND DIAGNOSING ATRIAL FIBRILLATION AND ESTABLISH A PATIENT-SPECIFIC STEM CELL PLATFORM FOR DEVELOPING PRECISION MEDICINE BASED TREATMENTS. | $175,006 | 2021 |
| University of Florida Foundation | Gainesville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO BROADEN THE DISCOVERY OF NEW PANCREATIC CANCER BIOMARKERS THROUGH GENOMIC SEQUENCING. BY SEQUENCING TUMOR AND NORMAL SAMPLES FROM OUR PATIENTS, WE CAN DETERMINE NOVEL CANCER DRIVERS INCLUDING MUTATIONS, FUSIONS, AND GENE EXPRESSION ALTERATIONS THAT DRIVE THESE CANCERS. NEW BIOMARKERS WILL INTRODUCE NEW POTENTIAL TARGETS FOR TREATMENT AND EARLY DETECTIONS. | $150,000 | 2021 |
| Israel Cancer Research Fund | New York, NY | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO ASK HOW DNA REPAIR IS ORCHESTRATED DESPITE THE PACKAGING OF DNA INTO CHROMATIN. SWI/SNF PROTEINS ESTABLISH AND MAINTAIN CHROMATIN STRUCTURE. SUBUNITS OF SWI/SNF PROTEINS ARE MUTATED IN 20% OF CANCERS, IMPLICATING THEM IN CARCINOGENESIS, AND MAKING THEM ATTRACTIVE CANDIDATES FOR CANCER-SPECIFIC AND SELECTIVE THERAPIES. DR. ADAR EXPECTS TO ESTABLISH THAT SWI/SNF REMODELERS FACILITATE SPECIFIC STEPS IN NUCLEOTIDE EXCISION REPAIR (NER) IN CHROMATIN TEMPLATES, AND THAT CANCER ASSOCIATED MUTANTS ARE DEFICIENT IN THIS FUNCTION. THIS NEW UNDERSTANDING OF SWI/SNF FUNCTIONS CAN THEN BE LEVERAGED TO DESIGN NEW CANCER DIAGNOSTICS AND CHEMOTHERAPEUTICS. | $148,500 | 2021 |
| University of Florida Foundation | Gainesville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO ASSESS POTENTIAL DRUG INTERACTIONS BETWEEN CANGRELOR AND NOVEL P2Y12 INHIBITORS AND EVALUATE THE IMPACT OF RECEPTOR EXPRESSION ON THEIR FINDINGS. | $125,000 | 2021 |
| Mayo Clinic | Jacksonville, FL | THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THIS GIFT TO SUPPORT THE TAPESTRY STUDY. | $9,763 | 2021 |
Grants to individuals are counted but not named.
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